Acute Stroke Trials
Coma: Prognosis of anoxic coma by MRI and serum markers for cerebral injury
This study is designed to asses whether DWI MRI can be obtained in most patients who remain comotose after cardiac arrest within the first few days, and whether the severity of DWI abnormality and the blood levels of biochemical markers of brain injury can predict neurologic outcome at 6 months after the arrest.
We are no longer enrolling for the following trials:
Blood Pressure and Perihematomal Injury: Pilot study evaluating the effect of BP treatment on perihematomal injury by serial MRIs in patients with intracerebral hemorrhage
In this study, with the help of novel MRI techniques, we aim to study the evolution of the edema around the blood clot, and also measure its response to different degrees of blood pressure lowering.
Clear IVH: Phase II Multicenter study evaluating rtPA treatment of patients with intraventricular hemorrhage
This study is designed to investigate the optimum dose frequency of rtPA administered via an intraventricular catheter to safely and effectively treat intraventricular hemorrhage (IVH) patients.
DEFUSE: DWI Evolution For Understanding Stroke Etiology (3-6h treatment window)
A study which will determine whether neuroimaging with MRI (DWI) can help identify patients that can benefit from thrombolytic therapy with rt-PA beyond the 3 hour treatment window.
DIAGNOSIS: (Diffusion weighted Imaging Assessment of the Genuine Need for Other Studies in Ischemic Stroke)
Patients with acute stroke (<48 hours) are evaluated with diffusion weighted MRI (DWI) and perfusion MRI. These new, non-invasive techniques are very sensitive at detecting acute brain injury and may be very helpful in guiding stroke evaluation and management.
DVT Study
A Study to Evaluate the Efficacy and Safety of Enoxaparin Versus Unfractionated Heparin (UFH) in the Prevention of Venous Thromboembolism (VTE) in Patients Following Acute Ischemic Stroke
ICTuS-L: Study evaluating hypothermia combined with rtPA in acute ischemic stroke (0-6 hour window.)
This study is designed to assess the safety and feasibility of the endovascular induction of hypothermia in patients presenting up to 6 hours of the onset of an acute ischemic stroke who are treated with tPA.
MRI in Vasospasm: DWI and PWI in aneurysmal subarachnoid hemorrhage
This study is designed to assess whether MRI, specifically perfusion-weighted imaging (PWI) and diffusion-weighted imaging (DWI), can be used to identify patients who are at increased risk for vasospasm and secondary cerebral ischemia.
PERFUSE: Improved PWI methodology in acute clinical stroke
This study is designed to improve the ability of PWI MRI to quantitatively map perfusion in patients with suspected stroke. This research study also uses Xenon CT scanning for the purposes of measuring cerebral blood flow in this patient population.
Selective Cerebral Hypothermia: Phase I study evaluating the feasibility and safety of selectively cooling the brain
This study tests an innovative technology that holds the promise of creating selective cerebral hypothermia within the brain only.
SENSE: Improving SENSE MRI for spiral and echo-planar imaging
This study is designed to demonstrate that SENSE can be combined with DWI/DTI to significantly improve the evaluation of patients with signs or symptoms of cerebral ischemia.
