rt-PA Treatment Criteria: (Modified from NINDS Criteria)
Inclusion Criteria:
- Clinical diagnosis of stroke
- Time of stroke onset (i.e. last time pt witnessed to be well) < 3 hours
- BP Systolic <= 185, diastolic <= 110 (can receive 1-3 doses of bp agent for control)
- Pro time <= 15 seconds or INR <= 1.7
- Platelet count >= 100,000
- Blood Glucose => 50 and <= 400 mg/dl
Exclusion Criteria:
- Minor stroke or rapidly resolving stroke
- Seizure at onset of stroke
- Heparin treatment during the past 48 hours with an elevated PTT
- Evidence of acute myocardial infarction
Exclusion Criteria (Relative Contraindications):
- History of prior intracranial hemorrhage, neoplasm, AVM or aneurysm
- Major surgical procedures within 14 days
- Stroke or serious head injury within 3 months
- Gastrointestinal or urinary bleeding within last 21 days
- Lactation or Pregnancy within 30 days
